Abstract
Amyloidosis is the extracellular fibril deposition of a variety of proteins, many of which circulate as plasma ingredients. It is a disease difficult to identify due to its nonspecific symptoms and manifestations. Amyloidosis of the tongue, either isolated or part of the systemic disease, is rare and its features resemble those of a tumor. We report the case of a patient with amyloidosis who presented with a tongue lesion, weakness, nonspecific arthritis, and dyspnea on exertion that resulted in multiorgan system failure.
Highlights
In western countries, incidence of AL amyloidosis is approximately 9 cases out of a million inhabitants per year, and AL amyloidosis occurs slightly more in men than in women [1]
Amyloidosis is classified on the basis of the precursor protein forming the fibril deposits (AL: primary or AA: secondary) and the distribution of amyloid deposition [2]
AL amyloidosis is the most common form of systemic amyloidosis and can respond to chemotherapy directed at the underlying plasma-cell dyscrasia
Summary
Amyloidosis is the extracellular fibril deposition of a variety of proteins, many of which circulate as plasma ingredients. It is a disease difficult to identify due to its nonspecific symptoms and manifestations. Amyloidosis of the tongue, either isolated or part of the systemic disease, is rare and its features resemble those of a tumor. We report the case of a patient with amyloidosis who presented with a tongue lesion, weakness, nonspecific arthritis, and dyspnea on exertion that resulted in multiorgan system failure
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