Abstract
Introduction: Since the first case of COVID-19 was confirmed in February 2020, Brazil has reported more than 20 million cases and more than 600,000 deaths on October 31, 2021. The behavior of the pandemic was also different in the various regions of the country, from those with less economic development to those with greater economic development, such as the state of São Paulo.
 Objective: to describe step-by-step time series for analyzing trends in mortality, lethality and incidence of COVID-19 in Brazil.
 Methods: a protocol for an ecological study of time series, covering the 26 states and the federal district (Brasilia).
 Results: The descriptions have the potential to provide information for the government and society in decision-making, about knowledge and conduct, clinical, epidemiological and research investments in health care for the Brazilian people. It is focused on fully understanding the spread of SARS-COV-2 infection in the Brazilian territory, and developing a database for public and universal access for comparative studies between countries and continents.
 Conclusion: database built from ecological studies are essential for a full understanding of the virus behavior, its transmissibility, lethality and mortality, and a repository for data that’s been collected and integrated from multiple sources. It is a relevant tool for the search of information and decision-making in global health.
Highlights
After the COVID-19 disease was declared a pandemic by the World Health Organization (WHO) in March 2020, governments and health authorities all over the world faced the difficult task of making decisions that seek to minimize the health, social and economic consequences of the pandemic
Why was this study done? The COVID-19 pandemic has hit Brazil hard, and the country has faced serious challenges to control the spread of the infection and prevent deaths from it
There is a lack of studies that analyze mortality, lethality, and incidence trends across Brazilian states
Summary
After the COVID-19 disease was declared a pandemic by the World Health Organization (WHO) in March 2020, governments and health authorities all over the world faced the difficult task of making decisions that seek to minimize the health, social and economic consequences of the pandemic. Closing borders, businesses, schools, non-essential establishments, and at the same time seeking strategies regarding when to reopen those activities and establishments[1]. Since the first case of COVID was confirmed in February 20202, cases reached more than Million and there were more than 600.000 deaths as of October 31, 2021 (Coronavirus panel). The country has a vast territory of more than 8,5Km2, Brazilian Institute of Geography and Statistics – IBGE3 and shares borders with ten countries in South America. The pandemic has shown different trends in the various regions of the country and the less economically developed regions have been heavily affected[4]
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