A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol.

Kalampaliki Kalampaliki,Skaltsounis Skaltsounis,Kostakis Kostakis,Giannouli Giannouli

doi:10.3390/molecules24183239

Kalampaliki Kalampaliki, Skaltsounis Skaltsounis + Show 2 more

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https://doi.org/10.3390/molecules24183239

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Abstract

Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation.

Highlights

IntroductionPolyphenols are aa wide found in in plant-based foods, such such as as cranberries, cranberries, Polyphenols are wide family family of of compounds compounds found plant-based foods, grapes, olives, and walnuts, and have many diverse biological activities
A few procedures describe the isolation of HT through the hydrolysis of oleuropein, a natural compound found mainly in olive tree leaves and other sources such as Ligustrum Vulgare [47,48,49,50,51]
As well as HT acetate and DHPG has been described in the present work, using simple, low-cost, and scalable procedures, starting from inexpensive, commercially available catechol

Summary

Introduction

Polyphenols are aa wide found in in plant-based foods, such such as as cranberries, cranberries, Polyphenols are wide family family of of compounds compounds found plant-based foods, grapes, olives, and walnuts, and have many diverse biological activities. One of the most important important components of the polyphenol family is hydroxytyrosol (HT), a simple o-diphenol found components of the polyphenol family is hydroxytyrosol (HT), a simple o-diphenol found in in leaves leaves and fruits of olive tree, virgin olive oil, as well as its wastewaters. It is derived from the hydrolysis and fruits of olive tree, virgin olive oil, as well as its wastewaters. It is derived from the hydrolysis of of oleuropein, preparation of table olives

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