Abstract
Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the anterior inferior iliac spine (AIIS). We conducted a chart review of 260 patients, analyzing three-dimensional (3D) reconstructed computed tomography (CT) images of the pelvis and sacrum to validate that this new approach offers a wide safety margin from the greater sciatic notch. Analysis of 3D CT scans demonstrated that the PSIS to AIIS trajectory never crossed the greater sciatic notch. The trajectory was noted to be at least one cm away from the greater sciatic notch in all measurements. The new trajectory entered the PSIS at 25.29 ± 4.34° (left side) and 24.93 ± 4.15° (right side) cephalad from the transverse plane, and 24.58 ± 4.99° (left side) and 24.56 ± 4.67° (right side) lateral from the midsagittal plane. The area of bone marrow encountered with the new approach was approximately 22.5 cm2. Utilizing the same CT scans, the trajectory from the traditional approach crossed the greater sciatic notch in all scans, highlighting the potential for violating the greater sciatic notch boundary, and damaging important neurovascular structures. Statistically, significant sex-related differences were identified in needle trajectory angles for both approaches. We conclude that based on this 3D CT study, a trajectory from the PSIS to the AIIS for BMA may offer a wide safety margin from the greater sciatic notch.
Highlights
Mesenchymal stem cells (MSCs) are an important cornerstone in cell-based transplantation and regenerative medicine therapy [1,2]
We propose an approach with the needle trajectory from the posterior superior iliac spine (PSIS) aimed toward the anterior inferior iliac spine (AIIS)
These images were analyzed to characterize an ideal trajectory for needle insertion during Bone marrow aspiration (BMA), the trajectory between the PSIS and AIIS and the relationship of this trajectory to the greater sciatic notch and other structures of the pelvis
Summary
Our objective was to investigate the safety of a recently described BMA technique, a trajectory from the posterior superior iliac spine (PSIS) to the anterior inferior iliac spine (AIIS)
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