Abstract
AbstractAn effective mask‐free method for fabricating high‐aspect‐ratio pillarlike nanostructures over a large area of a quartz surface via a simple O2 and CF4 two‐step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease markers.
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