Abstract
Introduction: Despite recent advances in surgical and adjuvant therapies for gastroesophageal cancer, it still remains the second leading cause of cancer deaths worldwide and is uniformly fatal in patients presenting with metastases and recurrence. This study set out to determine the effect of a third-generation replication-competent, oncolytic herpes simplex type I virus containing transgenes encoding for a fusogenic membrane glycoprotein and Fcy::Fur, against gastroesophageal cancer. Methods: The cytotoxic effect of the virus was tested on human gastroesophageal cancer cell lines OCUM-2MD3, MKN- 45, AGS, MKN-1, MKN-74, and BE-3.
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