A thermodynamic approach for predicting retention time characteristics in supercritical fluid chromatographs

Abstract

In this paper, we present a thermodynamic model that, in conjunction with relatively few data, can be used to predict retention time characteristics for entire classes of molecules in Supercritical Fluid Chromatography (SFC). For a given fluid-solid system, the solute parameter u b o can be evaluated a priori with a correlation derived from select data for a few model compounds. The parameter u b o reflects the well depth of the bound molecule-surface site interaction potential used in the lattice description of the bound species thermodynamic properties. Experimental data are provided testing the utility of the model for predicting behavior in SFC.