Abstract
The aim of this research was to control the delivery of naproxen from emulsion-based sodium phosphorylated chitosan (PCTS) nanoparticles (PCTS nanoemulsion) by thermal stimulus. The dynamic light scattering and optical microscope results demonstrated that the droplet size of emulsion-based nanoparticles was sensitive to temperature. The PCTS nanoemulsion exhibited the droplet size around 230 nm at 30°C. Emulsion droplets were increased in their size over critical temperature of around 60°C. Besides, the droplet size was reversible to 270 nm when the temperature decreased to 30°C. This indicated that the droplet size of PCTS nanoemulsion was sensitive to thermal stimulus. It might owe to molecular chain extension and rearrangement of PCTS at the interface of emulsion droplets. Therefore, the control release of naproxen from PCTS nanoemulsion via thermal stimulus was investigated.In vitrorelease study showed that the naproxen was released from PCTS nanoemulsion in high amount over critical temperature. These results indicated that the PCTS nanoemulsion exhibited a potential application as intelligent thermal sensitive drug carrier.
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