Abstract
HighlightsDOX-PLGA@CM employs the whole set of membrane molecules of a brain-homing metastatic breast cancer cell optimized through a natural selection process. Thus, the hetero and multivalent effects of these molecules greatly facilitate the nanoparticle crossing the blood-brain barrier.Attributed to the homotypic effect of the nanocarrier, DOX-PLGA@CM shows stronger anticancer efficacy than free DOX for its parenteral cells.DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, and slows down the progression of brain metastatic breast cancer.
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