A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells.

Samantha J Carrington,Pradip K Mascharak,Indranil Chakraborty,Jenna M L Bernard

doi:10.1021/acs.inorgchem.6b00511

A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells.

Samantha J Carrington, Pradip K Mascharak + Show 2 more

https://doi.org/10.1021/acs.inorgchem.6b00511

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Journal: Inorganic Chemistry	Publication Date: Apr 15, 2016
Citations: 76

Affiliation: University of California, Santa Cruz, University of California, Berkeley

#CO Photorelease #Change In Luminescence + Show 8 more

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Abstract

A Re(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re(H2O)(CO)3(pbt)](CF3SO3) (1), rapidly releases CO under low-power UV illumination. CO photorelease from 1 is accompanied by a change in luminescence from orange to deep blue. These two distinct luminescence signals have been successfully employed to track (a) the entry of the pro-drug 1 into cancer cells and (b) the end of the CO (drug) delivery step within the target.

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