Abstract
In this work, a new type of plaster based on chlorin e6 (Ce6)-gold nanorods (Au nrs) complex was developed for near-infrared (NIR) cancer therapy. The cancer treatment could be performed by applying the plaster to the tumor site and using dual-wavelength laser irradiation, 660nm and 808nm. The plaster could be irradiated repeatedly during the treatment and was completely noninvasive. It has exhibited broad, strong absorption in the NIR region, excellent photothermal efficiency and high singlet oxygen generation. The prepared plaster had low dark toxicity, while under irradiation, it showed high cell killing ability using human squamous cell carcinoma cells. The combinational effect of photothermal therapy (PTT) and photodynamic therapy (PDT) was also demonstrated in vivo. The plaster-treated tumor bearing mice showed highest therapeutic efficiency, compared to that treated with single PTT or PDT. The tumors have been destroyed completely after 16days treatment with the double phototherapy treatment. Therefore, the developed system might be potential as a dual-modal phototherapy way for cancer treatment in clinical application.
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