Abstract
Herein, we report a smart theranostic drug delivery system based on radial mesoporous silica, containing uIO for T2-weighted MRI and lIO for AMF-responsive chemotherapy.
Highlights
We report the construction of a novel theranostic drug delivery system based on radial mesoporous silica, which is hybridized with multiscale magnetic nanoparticles for MRI-guided and alternative magnetic field (AMF) responsive chemotherapy for breast cancer
Superparamagnetic iron oxide nanoparticles (IONPs) with multiscale sizes were prepared via a hydrothermal method and a thermal decomposition method. larger amino-terminal iron oxide nanoparticles (lIO NPs) act as the heat mediator that is responsive to the AMF, while ultra-small iron oxide nanoparticles (uIO NPs) act as the T2 contrast agent for MRI
Highly uniform radial IOMSN@uIO(DOX)-folic acid (FA) NPs exhibiting MRI contrast effects, active targeting properties and stimuli-responsive behaviors were successfully prepared through a simple so -template process for efficient chemotherapy of cancer
Summary
Since the rst anti-cancer drug was approved by the Food and Drug Administration (FDA) to treat hematological cancer, chemotherapy has been recognized as one of the key components of treatment for all stages of cancers, including early stage disease and patients with complete resection.[1,2,3] despite an expanding panel of chemotherapeutic agents such as paclitaxel, docetaxel, vincristine, pemetrexed, topotecan andOver the last decade, various drug delivery systems, such as micelles, liposomes, multifunctional dendritic polymers, nanospheres, nanocapsules, hydrogels and liquid crystals, have been successfully developed for efficient passive- or activetargeting delivery strategies.[10,11,12,13] each system possesses its own advantages, several signi cant limitations o en affect their further application. Qin Gao, ab Wensheng Xie,ab Yu Wang,ab Dan Wang,ab Zhenhu Guo,c Fei Gao,d Lingyun Zhao*ab and Qiang Cai*ab Both in vitro cytotoxicity analysis and in vivo anti-tumor effect evaluation demonstrated that the drug delivery system possesses great potential as an MRI-guided stimuli-responsive theranostic platform for effective active targeting chemotherapy of cancer.
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