Abstract
The combination of imaging and therapy has opened the very promising Theranostics domain with magnetic hyperthermia being a very promising domain. However, imaging systems should not interact with the magnetic field. In this work we have tested the recent C-series of SensL SiPM with 3mm pixel size, 4×4 arrays, coupled to different scintillators and irradiated with various gamma energies. The evaluation of the SiPM arrays shows that 1x1mm pixel size can be clearly resolved at PET energies for GAGG:Ce and CsI:Na and 1.5×1.5mm in SPECT imaging for CsI:Na. The best energy resolution was measured equal to 10.5% under 511keV irradiation for the 2×2mm GAGG:Ce; 16% under 511keV irradiation for the 1×1mm GAGG:Ce and 22% under 120keV irradiation for the 1×1mm CsI:Na. In addition, measurements with position sensitive photomultipliers have been carried out, to evaluate the effect of the magnetic field on the imaging performance of the system. While the effect of the magnetic field outside the coil is small, optimal images will be obtained if the imaging system is placed inside the coil, something that can be achieved only by using SiPMs.
Highlights
Radiolabelled magnetic nanoparticles are challenging agents for drug delivery in medicine
We have developed different detector modules based on Silicon Photomlutipliers (SiPM), which can serve as the basis for the development of SPECT and PET systems that can be used inside the magnetic field of the hyperthermia coil
The hyperthermia setup is based on a MP 6 kW instrument (Fives Celes, Lautenbach, France); The magnetic field is set by adjusting the voltage in the power supply, the frequency with an appropriate copper coil (∅ 110 mm, three turns), and an inductor set-up [H0 =25, f =173]
Summary
Radiolabelled magnetic nanoparticles are challenging agents for drug delivery in medicine. They can penetrate biological barriers, carry drugs on the target site, while minimizing dose in other organs. Simultaneous nuclear imaging during hyperthermia can provide insights in the biological process that occur when nanoparticles are heated [2]. In this way it is possible to monitor the successful organ/tumor targeting, drug release and/or real time response to therapy. This approach is by far superior when compared to the use of conventional anatomic or functional modalities, which can monitor the long term therapeutic effect
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