Abstract
THIS theory to explain gene expression in higher organisms is based on the spatial re-arrangement of genes by directed, specific folding of the chromosome. Tissue-specific differences in genome structure exist1 and profound modulation of genome structure can occur during differentiation2. It is postulated that specific proteins recognise specific sequences in double-stranded repetitive DNA and that, as a consequence, the structural genes encompassed by these repetitive sequences become accessible to the transcribing proteins. Transcription and translation then result in synthesis of proteins characteristic of the particular differentiated state. The interactions of metals and other ions with repetitive DNA (ref. 3) may be important in this recognition.
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