Abstract
The dorsal root potentials produced by dorsal root stimulation, as well as the monosynaptic reflexes and conduced responses of afferent fibers, were supressed after intra-arterial injections of tetrodotoxin (40–80 μg/kg). This poison also depressed, but did not abolish, the dorsal root potentials produced by direct stimulation of the dorsal horn. The tetrodotoxin-resistant portion of the directly elicited dorsal root potential had about the same time course and recovery characteristics as the dorsal root potentials evoked by afferent stimulation in the nonpoisoned spinal cords. This suggests that factors other than persistent activity of interneurons contribute to the prolonged duration of primary afferent depolarization.
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