Abstract
The effect of various agents which cause cell inactivation on the growth curves and RNA synthesis rates of chinese hamster ovary (CHO) calls has been studied. Agents which are known to act on DNA cause a reduced cell growth and RNA synthesis rate. Agents with a cytoplasmic target in eucaryotic cells cause a lengthened lag-phase, followed by growth and RNA-synthesis comparable to that of the control cells. From experiments with acrylonitrile, trichloroethylene, p-tetrachlorohydroquinone, cadmium chloride, and mercury chloride it is concluded that such studies can be used as a rapid test system for preliminary information as to whether a particuliar agent primarily damages the DNA of the cell nucleus or cytoplasmic structures in CHO cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
