A temporospatial histomorphometric analysis of bone density adjacent to acid-etched self-tapping dental implants with an external hexagon connection in the female baboon.

Abstract

To characterize osseointegration as the percent of bone-implant contact (%BIC) along the surface (0.0mm) as well as at surface profiles 0.5mm and 1.0mm lateral to the implant, determining any differences between early occlusally loaded and non-loaded implants. In ten adult female baboons, 120 dental implants were randomly placed in opposing mandibular and maxillary locations. Eighty sites had two groups of healing (no load) of either 1 (n = 40) or 2 (n = 40) months leading to 3months of functional loading. These sites received full acid-etched surface implants. The 40 control implants represented healing only periods (no load) for 1 (n = 10), 2 (n = 10), 4 (n = 10), and 5 (n = 10) months. These implants were of a vertically split surface texture design (acid-etched and machined). Block sections and photomicrographs were obtained. Blinded histometric analyses determined the %BIC via a superimposed template. The unloaded groups (1, 2, and 4months) had higher %BIC compared to the 5-month group (p < 0.0001). The loaded groups exhibited mean bone densities of 59.2% and 55.5% (1-month healing at 0.5mm and 1.0mm, respectively) and 61.0% and 57.1% (2-month healing at 0.5mm and 1.0mm, respectively) with no significant difference between healing time (p = 0.4118). There was a lateral increase in %BIC in the loaded compared to unloaded groups. The decrease in bone densities at the 5-month unloaded group suggests that there is a critical earlier time period when dental implants should be placed into functional load.