Abstract
ts 672 is a temperature sensitive mutant of the Prague strain of Rous sarcoma virus which fails to replicate infectious progeny virus at 41 °C. Chick embryo cells infected with ts 672 are transformed as evidenced by focus formation and increased rate of 2-deoxyglucose transport. Rescue of infectious progeny from ts 672-infected cells at 41 °C can be obtained by superinfection with avian leukosis viruses. Avian tumor virus group specific and type specific antigens can be detected in chick embryo cells infected with ts 672 at 41 °C, and physical particles that incorporate 3H-uridine and cosediment with avian tumor viruses on sucrose density gradients are produced in large numbers.
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