Abstract

THE QUANTITATIVE determination of the gastric acidity is important to the clinician because of the relationship between acid-pepsin, peptic ulcer, and gastric carcinoma. The clinical investigator also is interested in such determinations since he needs valid, quantitative data on the physiological responses of the gastrointestinal tract to food, sleep, and mental and physical stress. There is no indisputably physiological method available that yields such data. Gastric acidity is usually studied by inserting a tube into the empty stomach via the nose or mouth. This method has yielded much valuable information 1 but has the following objections: (1) The secretory response of only the empty stomach can be measured since food would clog the tube. (2) Aspiration of the acid gastric juice may cause an artificially high rate of secretion since the inhibitory effect of acid in the stomach is removed. (3) The presence of the tube in the nose or

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