Abstract
Physiology Proteinuria, the appearance of protein in the urine, results when podocytes in the kidney are damaged. Rinschen et al. found that the activation of the transcriptional coactivator YAP and the expression of YAP target genes preceded proteinuria in rats with chemically induced nephrosis. YAP activity can be stimulated by mechanical stress, and activation of YAP in cultured podocytes depended on the stiffness of the substrate. A YAP inhibitor ameliorated proteinuria and damage-induced mechanosignaling in the nephrotic rat kidneys. Sci. Signal. 10 , eaaf8165 (2017).
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