Abstract
A synthetic peptide representing residues 57–81 of the bovine P 2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P 2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60–81 produced a milder form of clinical disease. Residues 60–81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic α-helical structures.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.