Abstract
Red ginseng has been widely used in health-promoting supplements in Asia and is becoming increasingly popular in Western countries. However, its therapeutic mechanisms against most diseases have not been clearly elucidated. The aim of the present study was to provide the biological mechanisms of red ginseng against various metabolic diseases. We used a systems biological approach to comprehensively identify the component-target and target-pathway networks in order to explore the mechanisms underlying the therapeutic potential of red ginseng against metabolic diseases. Of the 23 components of red ginseng with target, 5 components were linked with 37 target molecules. Systematic analysis of the constructed networks revealed that these 37 targets were mainly involved in 9 signaling pathways relating to immune cell differentiation and vascular health. These results successfully explained the mechanisms underlying the efficiency of red ginseng for metabolic diseases, such as menopausal symptoms in women, blood circulation, diabetes mellitus, and hyperlipidemia.
Highlights
Metabolic diseases such as diabetes mellitus and cardiovascular disease manifest through a combination of various risk factors, such as low-grade inflammation, metabolic disorders, excess lipid accumulation, and loss of insulin sensitivity [1]
We have developed a comprehensive systematic approach for understanding the mechanisms by which red ginseng acts on metabolic disease and compared the pathways involved with those affected by white ginseng using a systems biology approach [22]
We we identified nine pathways affected only by red ginseng with give components
Summary
Metabolic diseases such as diabetes mellitus and cardiovascular disease manifest through a combination of various risk factors, such as low-grade inflammation, metabolic disorders, excess lipid accumulation, and loss of insulin sensitivity [1].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
