Abstract
AbstractPerforming reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi‐step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi‐step flow sequences can be realized. These tools are applied to the synthesis of 2‐aminoadamantane‐2‐carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self‐regulation to be managed by a single operator.
Highlights
Performing reactions in flow can offer major advantages over batch methods
During traditional batch-mode synthesis, researchers usually treat each step in isolation
In the area of machine-assisted flow synthesis,[1] the ability to insert analogous in-line processing operations between the individual steps is essential for procedures consisting of more than one chemical transformation.[2,3,4,5,6]
Summary
Performing reactions in flow can offer major advantages over batch methods. laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. We could identify the challenges for creating an integrated process: the first-generation flow procedure[13] (Scheme 1) was mostly conducted in singlestep operations with intermediate manual work-up operations.
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