A Systemic Review of the Relationship Between Aldosterone Synthase – 344 C/T Polymorphism and Hypertension in Han

Abstract

Many studies reported the association between aldosterone synthase gene CYP11B2 polymorphism and essential hypertension in Chinese. So far, no meta- analysis was conducted between the etiology of essential hypertension and CYP11B2 -344 C/T polymorphism in Han Chinese, the majority (93% of the total population) in China. Recruited literature was based on searching the Cochrane Library, MEDLINE, EMBASE, the Chinese Biomedicine Database (CBM), CNKI, VIP, and reference lists of articles without language restrictions. Nine studies with case-control involving 4259 unselected essential hypertension patients and 3213 controls were included in the analysis. From the nine homogeneous studies with gender, age, and ethnicity matched controls, we found no significant association between the etiology of essential hypertension and the -344 C/T variant in Han Chinese with random effect models (for homozygous CC: odds ratio (OR), 1.04, 95% confidence interval (CI), 0.791.37, P = 0.79; for allele C: OR, 1.04, 95% CI, 0.921.18, P = 0.56). No significant association was observed between CYP11B2 -344 C/T polymorphism and hypertension susceptibility in both sexes. Current large sample analysis did not support the association between the etiology of essential hypertension and CYP11B2 - 344 C/T polymorphism in Han Chinese.