A Systematic Scoping Review of Surgically Manipulated Adipose Tissue and the Regulation of Energetics and Body Fat in Animals.

Abstract

Surgical manipulations of adipose tissue by removal, or partial lipectomy, have demonstrated body fat compensation and recovered body weight, suggesting that the body is able to resist changes to body composition. However, the mechanisms underlying these observations are not well-understood. The purpose of this scoping review is to provide an update on what is currently known about the regulation of energetics and body fat after surgical manipulations of adipose tissue in small mammals. PubMed and SCOPUS were searched to identify n=64 eligible studies. Outcome measures included: body fat, body weight, food intake and circulating biomarkers. Surgeries performed included: lipectomy (72%) or transplantation (12%) in mice (35%), rats (35%), and other small mammals. Findings suggested that lipectomy did not have consistent long-term effects on reducing body weight and fat since regain occurred within 12–14 weeks post-surgery. Hence, biological feedback mechanisms act to resist long-term changes of body weight/fat. Further, whether this weight and fat regain occurred due to “passive” and “active” regulation under the “set-point” or “settling-points” theories cannot fully be discerned due to limitations in study designs and data collected. In conclusion, the regulation of energetics and body fat are complex and dynamic processes that require further studies of the interplay of genetic, physiological, and behavioral factors.