Abstract
Autism Spectrum disorder (ASD) is charecterised by certain degrees of disabilities in social communication, restrictive repetitive behaviour and altered motor and sensory perception. Translational research is carried out by creating animal models of autism to find out the correlation between behavioural changes and the pathology of brain tissue and for clinical trials of newer therapeutic formulations. Valproate induced animal model of autism has significant validity to demonstrate ASD manifestations. An early appreciation of ASD symptoms is needed for a better prognosis. So assessment of behavioural abnormalities and development stones in the first month of animal life are much important to study ASD.An extensive literature search was done on different databases. (PUBMED-MeSH, PMC, Webof Science, Google scholar and Research Gate). Original articles reported between the years 2000-2020 were selected. PRISMA protocol was followed. There are good quantities of studies on behavioural assessment of valproate induced animal model. This review explains the pathophysiology and various treatment modalities tried in valporate induced animal model and it also enlists the developmental and behavioural assessment methods of rat off springs. It will be useful to demonstrate all signs of autism.
Highlights
Autism spectrum disorder (ASD) is the neurodevelopmental disorder in which the affected individuals exhibit a different range of behavioural abnormalities like social impairment, poor communication skills, and repetitive behaviour
In rural and urban settings, the percentage prevalence of ASD is around 0.11 and 0.09 in children aged 0-15 years respectively [1].Genetics and the environment play an important role in the normal development of the brain
Original articles that have been done on animal models of autism and neurobehavioural assessment tests for rat offsprings were searched in the database of PUBMED-MeSH, Google Scholar, Science Direct, and Web of science
Summary
Autism spectrum disorder (ASD) is the neurodevelopmental disorder in which the affected individuals exhibit a different range of behavioural abnormalities like social impairment, poor communication skills, and repetitive behaviour. In rural and urban settings, the percentage prevalence of ASD is around 0.11 and 0.09 in children aged 0-15 years respectively [1].Genetics and the environment play an important role in the normal development of the brain. Behavioural disorders may be due to a combination of contributions from the environment and genetics. Physiology of regeneration of the nervous system is a very complicated process; any small alteration in the nervous system during the developing stage is expected to be irreversible. Diagnosis is delayed due to lack of awareness.
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