Abstract
BackgroundCOVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is, directly and indirectly, affecting all of us and thus, is an emerging topic dealt in global health. To avoid the infection, various studies have been done and are still ongoing. COVID-19 cases are reported all over the globe, and among the millions of cases, genetic similarity may be seen. The genetical common features seen within confirmed cases may help outline the tendency of infection and degree severity of the disease. Here, we reviewed multiple papers on SNPs related to SARS-CoV-2 infection and analyzed their results.MethodsThe PubMed databases were searched for papers discussing SNPs associated with SARS-CoV-2 infection and severity. Clinical studies with human patients and statistically showing the relevance of the SNP with virus infection were included. Quality Assessment of all papers was done with Newcastle Ottawa Scale.ResultsIn the analysis, 21 full-text literature out of 2956 screened titles and abstracts, including 63,496 cases, were included. All were human-based clinical studies, some based on certain regions gathered patient data and some based on big databases obtained online. ACE2, TMPRSS2, and IFITM3 are the genes mentioned most frequently that are related to SARS-CoV-2 infection. 20 out of 21 studies mentioned one or more of those genes. The relevant genes according to SNPs were also analyzed. rs12252-C, rs143936283, rs2285666, rs41303171, and rs35803318 are the SNPs that were mentioned at least twice in two different studies.ConclusionsWe found that ACE2, TMPRSS2, and IFITM3 are the major genes that are involved in SARS-CoV-2 infection. The mentioned SNPs were all related to one or more of the above-mentioned genes. There were discussions on certain SNPs that increased the infection and severity to certain groups more than the others. However, as there is limited follow-up and data due to a shortage of time history of the disease, studies may be limited.
Highlights
Introduction and backgroundIn 2020, coronavirus disease 2019 (COVID-19) posed a serious global public health threat
In this systematic review, we aimed to discover the related single-nucleotide polymorphisms (SNPs) of SARS-CoV-2 infection by going through all the SNPs mentioned in multiple papers on the identical topic
Out of 2956 papers searched initially, 21 academic papers were selected for the systematic review (Fig. 1). 21 papers discussing and analyzing genetic factors related to infection with SARS-CoV-2 were reviewed. 18 of them were published in 2020, and 3 were published in 2021
Summary
Introduction and backgroundIn 2020, coronavirus disease 2019 (COVID-19) posed a serious global public health threat. Suh et al BMC Infectious Diseases (2022) 22:47 coronavirus 2 (SARS-CoV-2) is important. Certain gene expressions are found to be closely related to coronavirus infection. Since SNP frequency and existence vary among population groups, groups with gene expression-related SNPs may show higher vulnerability to COVID-19 infection. Ethnicity could be suggested as a possible factor affecting the severity of SARS-CoV-2 infections [3]. COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is, directly and indirectly, affecting all of us and is an emerging topic dealt in global health. The genetical common features seen within confirmed cases may help outline the tendency of infection and degree severity of the disease. We reviewed multiple papers on SNPs related to SARS-CoV-2 infection and analyzed their results
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