Abstract
Abstract: The recent poisoning of Russian opposition figure and critic Alexei Navalny on August 20th , 2020 with a Soviet-era Novichok nerve agent reminded the world of the use of chemical agents, especially nerve agents to eliminate individual targets or for mass destruction. Nerve agents are a class of organophosphorus compounds. Soman, Sarin, Tabun, Cyclosarin, VX are a few examples of nerve agents. Nerve agents affect a person by disrupting the mechanism by which nerve signals are passed in the body. They inhibit the action of acetylcholinesterase enzyme which is responsible for the breakdown of acetylcholine neurotransmitters leading to accumulation of acetylcholine in the body. Nerve agents have a range of chemical effects on the eye, gastro-intestinal (GI) tract, Central nervous system (CNS), Respiratory system, Cardiovascular system and Neurological system. The management of nerve agent poisoning is done by administering Atropine or Pralidoxime chloride or also by administering anticonvulsants like Benzodiazepines or Diazepam. This review presents all such detailed information on this class of chemical Warfare agents. Keywords: Chemical Warfare Weapon, Nerve Agents, Acetylcholinesterase, Toxicity, Instrumentation
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