Abstract
Traditional Chinese Medicine prescription Suanzaoren decoction (SZRD) is composed of Ziziphi Spinosae Semen, Chuanxiong Rhizoma, Anemarrhenae rhizoma, Poria and Licorice. It was used to treat central nervous system diseases such as insomnia and anxiety for thousands of years. This paper aims to systematically understand varieties and quantities of compounds and clarify chemical components of SZRD, subsequently to further provide the reference for phytochemistry and pharmacology researches of SZRD. Our results showed that SZRD contained 145 components, including flavonoids, triterpenoids, steroids, coumarins, phthalides, and volatile oils, etc., while five-single herbs contain 1104 components. Only in terms of compound number, there were 80 common components in SZRD and its five herbs, which accounted for 6.8% of total compounds in all 5 herbs and 55.2% of compounds in SZRD. The components of SZRD were not simply the sum of one in every single herb. It is necessary to perform parallel studies among SZRD and its herbs. This review discussed the problems that existed in the chemical research of SZRD and pointed out the direction for its further research.
Highlights
These 48 components were characterized in Suanzaoren decoction (SZRD) using liquid chromatography time-of-flight mass spectrometry (LC-Q/TOFMS) and liquid chromatography coupled with ion trap mass spectrometry (LC-IT-MS) technology and 31 compounds were identified for the first time [111]
Ingredients between Suanzaoren Decoction and Herbs After comparing 145 compounds in SZRD with 1104 in 5 herbs, We found there were 80 common components which accounted for 6.8% of total compounds in all herbs and 55.2% of compounds in SZRD (Figure 3(a)), containing 7 categories, including 27 flavonoids, 17 triterpenoids, 12 steroids, 5 volatile oils, 4 coumarins, 14 phenolic acids and 1 alkaloid (Figure 3(b)) and found that 14 compounds came from Ziziphi Spinosae Semen, 18 from Chuanxiong Rhizoma, 15 from Anemarrhenae rhizoma, 9 from Poria and 27 from Licorice
Our study elucidated that components of SZRD were not the sum of one in every single herb
Summary
Suanzaoren decoction (SZRD), a classic Traditional Chinese Medicine (TCM) prescription, was first described in the book “Jin Gui Yao Lue” by Zhongjing. SZRD is consists of five herbs, Suanzaoren Clinical researches showed that the combination of SZRD and other drugs, including TCM and chemicals, can improve insomnia [13] [14] [15] [16], anxiety [16] [17] [18], depression [19] [20] and other diseases [21], enhance the efficiency of treatment, and reduce adverse reactions. The clinical therapeutic effect and pharmacological function of SZRD originate in its chemical composition. We investigated and analyzed chemical ingredients of SZRD and its five-single herbs on basis of literatures in the last 5 years and calculated the percentage based on compounds number of a certain class in the total number of compounds. We focused on similarities and differences of ingredients between SZRD and its herbs
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