Abstract
Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers. Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria. Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion. Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.
Highlights
Cancer is a set of complex processes, including unlimited cell proliferation, death of impaired cells, and spatial-temporal changes in cell physiology, that may result in the formation of malignant tumors with the potential for metastasis (Seyfried and Shelton, 2010)
A flavone glycoside, is promising for the treatment of many diseases due to its low cost, broad availability, long history of use, and variety of pharmacological actions, with the predominant evidence currently focusing on its anticancer impacts
Combined with other drugs may be useful for treating cancers
Summary
Cancer is a set of complex processes, including unlimited cell proliferation, death of impaired cells, and spatial-temporal changes in cell physiology, that may result in the formation of malignant tumors with the potential for metastasis (Seyfried and Shelton, 2010). Fruit-based cancer preventive and therapeutic entities, such as flavonoid and their derivatives, have shown a noticeable capability to suppress tumor formation and cancer cell growth (Ramesh and Alshatwi, 2013). Flavonoids are a big class of natural polyphenols, existing in a broad variety of vegetables and fruits commonly consumed by humans. These phytochemicals are divided into different subclasses, including flavonols, flavan-3-ols, isoflavones, flavanones, anthocyanidins, and flavones (Romagnolo and Selmin, 2012). Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers
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