Abstract
Purpose Although doxorubicin chemotherapeutic drug is commonly used to treat various solid and hematological tumors, its clinical use is restricted because of its adverse effects on the normal cells/tissues, especially cardiotoxicity. The use of resveratrol may mitigate the doxorubicin-induced cardiotoxic effects. For this aim, we systematically reviewed the potential chemoprotective effects of resveratrol against the doxorubicin-induced cardiotoxicity. Methods In the current study, a systematic search was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline for the identification of all relevant studies on “the role of resveratrol on doxorubicin-induced cardiotoxicity” in the electronic databases of Web of Science, PubMed, and Scopus up to March 2021 using search terms in their titles and abstracts. Two hundred and eighteen articles were screened in accordance with a predefined set of inclusion and exclusion criteria. Finally, 33 eligible articles were included in this systematic review. Results The in vitro and in vivo findings demonstrated a decreased cell survival, increased mortality, decreased heart weight, and increased ascites in the doxorubicin-treated groups compared to the control groups. The combined treatment of resveratrol and doxorubicin showed an opposite pattern than the doxorubicin-treated groups alone. Furthermore, this chemotherapeutic agent induced the biochemical and histopathological changes on the cardiac cells/tissue; however, the results (for most of the cases) revealed that these alterations induced by doxorubicin were reversed near to normal levels (control groups) by resveratrol coadministration. Conclusion The results of this systematic review stated that coadministration of resveratrol alleviates the doxorubicin-induced cardiotoxicity. Resveratrol exerts these chemoprotective effects through several main mechanisms of antioxidant, antiapoptosis, and anti-inflammatory.
Highlights
Cancer, the uncontrolled growth of cells, is the second leading cause of death in the world [1,2,3], and its incidence and mortality are rapidly growing [4]
The results showed that there was a direct relation between the decreased cell count and posttreatment time/chemotherapy dosage [32, 34, 37, 39, 42]
The results demonstrated that the body weight and heart weight of mice/rats were reduced in the doxorubicin groups than in the control groups [38, 43, 45,46,47,48,49,50,51,52]
Summary
The uncontrolled growth of cells, is the second leading cause of death in the world [1,2,3], and its incidence and mortality are rapidly growing [4]. Doxorubicin-induced cardiotoxicity is a serious adverse effect and can reduce quality of life and sometimes fatalities, leading to restriction of the clinical use of this chemotherapy drug [15]. In this regard, the use of chemoprotective agents during doxorubicin treatment has been suggested which may mitigate the adverse effects and improve patient survival. Risk of bias in individual studies Summary measures Synthesis of results Risk of bias across studies Additional analyses Results Study selection. Study characteristics Risk of bias within studies Results of individual studies Synthesis of results Risk of bias across studies Additional analysis # Checklist item.
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