Abstract
In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico.
Highlights
Pesticide application remains the most effective and accepted practice for crop protection, contributing significantly to the increase of agricultural productivity [1]
The measurement of the response can be physiological, biochemical, and cellular or molecular level. These may allow the identification of susceptible groups or individuals with higher or lower risk due to exposure to certain types of environmental and/or occupational agents [77]
These results suggested that the interaction between maternal floriculture work during pregnancy and the 192RR Paraoxonase 1 (PON1) genotype increased the probability of having children with low birth weight (LBW)
Summary
Pesticide application remains the most effective and accepted practice for crop protection, contributing significantly to the increase of agricultural productivity [1]. Due to their persistence, pesticides are ubiquitous pollutants of our environment and have been found in air, soil, water, as well as in human and animal tissues [2]. Pesticides are ubiquitous pollutants of our environment and have been found in air, soil, water, as well as in human and animal tissues [2] They differ greatly in their mode of action, form, metabolism, elimination, and toxicity in the organism.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
