Abstract
Vitamin E is a fat-soluble vitamin and an antioxidant that prevents the peroxidation of lipid in vitro. The antioxidant role of vitamin E in preventing adverse cardiovascular outcomes is controversial as some studies support it, while others reject it. Therefore, this review aims to determine whether there is an association between vitamin E and cardiovascular diseases (CVDs). An electronic search was done to find out relevant articles. Papers were shortlisted after the initial title and abstract screen. A full-text study was done, and inclusion and exclusion criteria were applied before the quality assessment of each paper was done. Only high-quality papers were selected for analysis. Full-text articles of the last ten years were included, while non-English articles, gray literature, and animal studies were excluded. The majority of the papers, including 75% of the total population in this review, suggested no role of vitamin E in preventing CVD and CVD mortality. Some studies also suggested that a high level of vitamin E can be associated with adverse cardiovascular outcomes. Thus, one should be prudent about taking vitamin E supplementation for cardiovascular risk prevention.
Highlights
BackgroundWith the increase in advancement in medicine and the health care delivery system, the major cause of morbidity and mortality of the human population is progressively shifting from infectious diseases to noncommunicable diseases
We attempted to determine the protective role of vitamin E, if there is any, against the adverse cardiovascular outcomes in this paper
We concluded that there is no significant correlation between vitamin E and cardiovascular risks
Summary
With the increase in advancement in medicine and the health care delivery system, the major cause of morbidity and mortality of the human population is progressively shifting from infectious diseases to noncommunicable diseases. Among various important non-communicable diseases, cardiovascular diseases (CVDs) are the major causes of morbidity and mortality. The total deaths due to CVD in 2016 were nearly one-third of all deaths worldwide [1]. In 2017, CVD led to over 330 million years of life lost and 35.6 million years of life lived with disability worldwide [2,3]. The total number of deaths due to CVD in 2017 was over 17 million, and more than 23 million deaths are expected to occur in 2030 across the globe if this rate continues [4]
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