Abstract
A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer¿s disease
Highlights
The aim of this review was to investigate whether there is a faster cognitive decline in dementia with Lewy bodies (DLB) than in Alzheimer’s disease (AD) over time
Subgroups with different cognitive profiles have been described in patients with Parkinson’s disease (PD) [9], and there is evidence that this differentiation is related to the rate of cognitive decline [10]
Of the 18 studies included in this review, six (36%) reported a statistically significant difference in cognitive decline over time between AD and DLB
Summary
The aim of this review was to investigate whether there is a faster cognitive decline in dementia with Lewy bodies (DLB) than in Alzheimer’s disease (AD) over time. Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are the two most common subtypes of neurodegenerative dementia, representing 15 to 20% and 65% of all dementia cases, respectively [1]. There is some evidence that DLB patients have more rapidly progressing dementia compared to AD [3], and more recent studies reported a more. Subgroups with different cognitive profiles have been described in patients with PD [9], and there is evidence that this differentiation is related to the rate of cognitive decline [10]. Similar neuropsychologically defined subgroups may exist in DLB [8], which could predict differences in the rate of progression to end-stage dementia. Data supports accelerated disease progression when AD and DLB pathologies are present together [11]
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