Abstract
BackgroundIt is known that risk of chronic kidney disease (CKD) is elevated in patients with diabetes mellitus but it is not clear whether the risk is also elevated with impaired glucose tolerance (IGT). If the risk is increased, it is not known if this is confined to people with IGT who progress to type 2 diabetes (T2DM). The purpose of this systematic review is to determine the relative risk of CKD in young adults (aged 18 to 40 years) with IGT (exposed group) compared to those without glycaemic abnormality (comparator group).Methods/DesignThe following electronic databases will be systematically searched from inception to January 2015 for relevant studies: CINAHL, EMBASE, MEDLINE, PubMed, Cochrane libraries and grey literature. Two independent reviewers will screen search results, extract data, select studies for inclusion and assess their quality. Studies including young adults (aged 18 to 40 years) with IGT containing any of the following CKD markers will be included: estimated glomerular filtration rate (eGFR), albumin creatinine ratio (ACR), protein creatinine ratio (PCR), serum creatinine (SCr) and creatinine clearance (CrCl) levels. Studies at any time period after diagnosis of IGT and with any length of follow-up will be included. The proportion of IGT participants reporting each outcome will be documented. Relative risks (RR) and odds ratios (OR) will be extracted or calculated from raw data. If possible, study results will be combined in a meta-analysis.DiscussionThe results of this comprehensive review will establish the evidence for the association between IGT and the risk of developing CKD in young adults (aged 18 to 40 years).Systematic review registrationPROSPERO CRD42014007081Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-015-0059-6) contains supplementary material, which is available to authorized users.
Highlights
It is known that risk of chronic kidney disease (CKD) is elevated in patients with diabetes mellitus but it is not clear whether the risk is elevated with impaired glucose tolerance (IGT)
The results of this comprehensive review will establish the evidence for the association between IGT and the risk of developing CKD in young adults
Search An optimal search strategy has been developed; an additional file shows this in more details which focuses on the following key terms: chronic kidney disease, impaired glucose tolerance, type 2 diabetes and young adult
Summary
This systematic review will synthesise research evidence to establish whether the risk of developing CKD is relatively high in young adults with IGT and gather information on IGT progression to T2DM and development of CKD in this age group. Limitations may include the quality of data extracted which may not allow studies to be combined in a meta-analysis. This may be overcome by presenting the findings in a descriptive manner. Additional file 2: Data extraction form adapted from Hayden et al [21]. Additional file 3: Quality assessment form adapted from the Ottawa-Newcastle scale (NOS) for assessing non-randomised studies. Quality assessment form adapted to reflect the nature of cohort and case–control studies related to CKD outcomes.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
