Abstract
Background: Chronic spontaneous urticaria (CSU) is a common recurrent skin disease that adversely affect patient's quality of life condition to treat. Economic evaluations of health care often include patient preferences for health outcomes using utilities.Objectives: The study aimed to determine pooled estimates of utility-based quality of life in patients with CSU.Methods: We conducted a systematic review, meta-analysis, and meta-regression of peer-reviewed articles and conference papers that published from database inception to 31 April 2019 that reported utility estimates in patients with CSU. Scores reported with the EQ-5D, SF-6D, SF-12, and SF-36 instruments were converted to utilities using published mapping algorithms. Meta-analysis was used to calculate the pooled and meta-regression was used to examine the effects of possible factors.Results: The pooled utility estimate for CSU was 0.68 [95% confidence interval (CI): 0.67–0.70]. The pooled utility estimate that converted from SF-36 or SF-12 was 0.66 (95% CI: 0.58–0.74), 0.72 (95% CI: 0.70–0.74) for EQ-5D, and 0.65 (95% CI: 0.63–0.67) for SF-6D, respectively. According to the meta-regression, higher proportion of female patients was significantly associated lower utility estimates (p = 0.013).Conclusions: The study provides evidence-based utility estimates to inform health-related burden analysis of CSU and reference for the follow-up cost-effectiveness evaluation of chronic spontaneous urticaria intervention. These results highlight differences in common utility-based instruments and need to be cognizant of the specific instruments used when comparing the results of outcome studies.
Highlights
Chronic urticaria (CU) is defined as the spontaneous appearance of wheals, angioedema, or both, for more than 6 weeks due to known and unknown causes
CU can be divided into chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIU) [1]
Studies that reported estimates from health-related quality of life scores were excluded unless all eight Short Form-36 (SF-36) domains were reported separately, and a utility estimate could be calculated, as above
Summary
Chronic urticaria (CU) is defined as the spontaneous appearance of wheals, angioedema, or both, for more than 6 weeks due to known and unknown causes. Utility of Chronic Spontaneous Urticaria the point prevalence of CU diagnosis in the United States and five European countries is 0.53 and 0.63%, respectively [2,3,4]. The disease is most common in patients aged 20–40 years, but can be observed in all age groups [5]. Studies have consistently shown that women are almost twice as likely as men to develop the disease [3, 4, 6, 7]. Chronic spontaneous urticaria (CSU) is a common recurrent skin disease that adversely affect patient’s quality of life condition to treat. Economic evaluations of health care often include patient preferences for health outcomes using utilities
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