Abstract
To assess and update the effect of the combination of vitamin D and calcium in the reduction of osteoporotic fractures, a systematic review across Cochrane Database, NIHRHTAdatabase, PubMed and Google Scholar was performed using mesh terms :Cohortstudies OR ProspectiveStudies OR LongitudinalStudies OR Follow-UpStudies OR Incidence OR Risk OR Rate and Osteoporotic Fractures OR Fractures, Bone OR Fractures, Spontaneous OR Spinal Fractures OR Humeral Fractures OR Hip Fractures ORFemoral Neck Fractures AND Vitamin D AND Calciumand key words: vitamin D, fractures, osteoporosis,calcium, dietary supplements. Statistical analysis was performed with Review Manager (RevMan 5.3) using relative risk and confidence interval 95%. The combination reduced total fractures and hip fractures while no effect was observed in wrist fractures. The combination was also well tolerated. Only minor side effects were reported. This systematic review suggests that the combination of vitamin D and calcium can exert a beneficial effect towards osteoporotic fracture reduction.
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