Abstract
A systematic review and meta-analysis of the data behind current recommendations for corticosteroids for non-HIV related PCP; Knowing when you are on shaky foundations
Highlights
Research during the early AIDS epidemic fueled major advances in prevention and management of HIV-related Pneumocystis pneumonia (HIV-Pneumocystis Jiroveci Pneumonia (PCP)) [1,2,3,4]
The literature does not support an association between adjunctive corticosteroids and survival from non-HIV PCP (NH-PCP) but data are limited and findings should not be considered conclusive
We limited studies to human subjects and searched for the following terms: (Pneumocysti* [text word] odds ratios (OR) PCP[text word] OR “Pneumocystis Infections” [MESH] OR “Pneumocystis jirovecii” [MESH] OR “Pneumonia, Pneumocystis” [MESH] OR “Pneumocystis carinii”[MESH]) AND NOT (“animals”[MeSH] NOT “humans” [MeSH]) In addition, we examined the references of all identified articles to look for additional relevant articles
Summary
Research during the early AIDS epidemic fueled major advances in prevention and management of HIV-related Pneumocystis pneumonia (HIV-PCP) [1,2,3,4]. The use of adjunctive corticosteroids for treatment of severe HIV-PCP (Pa02
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