Abstract
ObjectiveSerous ovarian carcinoma is the most common histological type of ovarian cancer, with high-grade serous ovarian carcinoma (HGSOC) being more common than low-grade serous ovarian carcinoma (LGSOC). Despite pathogenic and clinical differences, both grades of serous ovarian carcinoma share the propensity to express receptors for the female hormones – oestrogen (ERs) and progesterone receptors (PRs) – albeit in differing frequencies. Study designSystematic review and meta-analysis of studies reporting the expression of hormone receptors in LGSOC, and comparison with expression in HGSOC. ResultsExpression of ERs is observed in 80.7 % of patients with LGSOC [95 % confidence interval (CI) 72.2–89.1 %] and 61.5 % of patients with HGSOC (95 % CI 38.8–84.1 %). Expression of PRs is observed in 54.4 % of patients with LGSOC (95 % CI 44.3–64.4 %) and 30.7 % of patients with HGSOC (95 % CI 15.7–45.7 %). ConclusionA higher percentage of LGSOCs are positive for ER expression compared with HGSOCs. Similarly, a higher percentage of LGSOCs are positive for PR expression, although PR expression is lower than ER expression. Expression of hormone receptors may represent a therapeutic opportunity for treatment with agents that block their activity, especially in LGSOC which is less responsive to chemotherapy and therapeutic options are limited.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Obstetrics & Gynecology and Reproductive Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
