Abstract
Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or without growth factors.
Highlights
Venous disease is a pathological chronic condition that causes significant morbidity and decreases quality of life in affected patients
The pathophysiology of the venous ulcers is explained by the venous hypertension which lead to increased pressure in the distal veins of the leg; fibrin cuff theory in which the fibrin gets excessively deposited around capillary beds leading to elevated intravascular pressure causing enlargement of endothelial pores resulting in a further interstitial fibrinogen deposition increase
Since those 12 articles did not focus in fibrin matrix with autologous growth factors, they were excluded from the review
Summary
Venous disease is a pathological chronic condition that causes significant morbidity and decreases quality of life in affected patients. Patients with chronic peripheral vascular disease of venous origin exhibit secondary ulcer complications in skin and soft tissues of the lower limbs, with recurrence rates of 45% to 70% per year during the course of the patients disease, which makes it difficult to manage[2]. The pathophysiology of the venous ulcers is explained by the venous hypertension which lead to increased pressure in the distal veins of the leg; fibrin cuff theory in which the fibrin gets excessively deposited around capillary beds leading to elevated intravascular pressure causing enlargement of endothelial pores resulting in a further interstitial fibrinogen deposition increase. The dysregulation of various pro-inflammatory cytokines and growth factors like tumor necrosis factoralpha, transforming growth factor (TGF) beta and matrix metalloproteinases lead to chronicity of the ulcers
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