Abstract
BackgroundCanine parvovirus 2 (CPV-2) is a pathogenic virus that infects dogs, causing a highly infectious disease. Monitoring CPV-2 spread is an important part of prevention; however, the prevalence and epidemiological characteristics of CPV-2 have not been systematically evaluated and analyzed in mainland China. Therefore, a systematic review and meta-analysis were performed to assess prevalence and epidemiological characteristics of CPV-2 in domestic dogs in mainland China.MethodsIn this study, Chinese and English literature on CPV-2 epidemiology published between January 2006 and December 2019 was evaluated. Regarding meta-analysis, the random-effect model was employed by forest plot with 95% of confidence interval. The number of CPV-2 infections was identified and the pooled prevalence of infection, as well as the epidemiological characteristics, was calculated using meta-analysis.ResultsA total of 39 studies (data from 137,844 dogs) met the evaluation criteria and were used in our study. The pooled prevalence of CPV-2 infection in mainland China was 36%. CPV-2 infection were associated with age, breed, sampling season and immunization status, but not with gender, publication time and diagnostic methods.ConclusionsOur results indicated that CPV-2 is prevalent among dogs in China. It is therefore necessary to carry out continuous surveillance and epidemiological studies of CPV-2. In addition, accordingly, effective measures should be taken to prevent the transmission and spread of CPV-2 among the Chinese dog population.
Highlights
Canine parvovirus 2 (CPV-2) is a pathogenic virus that infects dogs, causing a highly infectious disease
Studies have shown that CPV-2 is a variant of the feline parvovirus (FPV)-like virus that was found in faecal samples from dogs with diarrhoea and quickly spread around the world [6]
This study focussed on a systematic review and meta-analysis to summarise the prevalence of CPV-2 and examine the potential risk factors of CPV-2 infection in mainland China
Summary
Canine parvovirus 2 (CPV-2) is a pathogenic virus that infects dogs, causing a highly infectious disease. A systematic review and meta-analysis were performed to assess prevalence and epidemiological characteristics of CPV-2 in domestic dogs in mainland China. CPV-2 is a potentially fatal pathogen in domestic dogs and other canine species. It may infect other animals, such as cats because it has evolved into variant types that can infect cats [5]. The analysis of animal virus infection rates and epidemiological characteristics is necessary to reduce the risk of cross-species transmission between animals and humans and to prevent the potential threat of animal virus pandemic among humans
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