Abstract
Adhatoda vasica (L.), Nees belonging to the family Acanthaceae is a shrub with opposite ascending branches. The plant has been used in the indigenous system of medicine in India for near about 2500 years. It is a well-known plant as a drug in Ayurvedic and Unani medicines. Traditionally it was used for the treatment of various acute and chronic diseases and showed strong pharmacological activity particularly for bronchial infections, cough, bacterial infections, reproductive disorders, cardiac diseases and many more. Various phytochemicals like alkaloids, flavonoids, tannins, etc. were obtained from Adhatoda vasica (A. vasica). The active constituent of the plant is vasicine, l-vasicinone, deoxyvasicine, maiontone, vasicinolone and vasicinol etc. This review consists of updated information on the phyto-constituents isolated from A. vasica and their potential role in the treatment of various ailments traditionally and medically. Based on the critical review it was concluded that there is not sufficient scientifically strong evidence to explain that A. vasica extract, could be harmful to human beings especially in pregnant women. Major data on traditional uses as well as toxicological studies, evaluated various correctness, relevance, importance, and reliability for the overall evaluation of A. vasica safety. Numerous clinical trials are conducted around the globe on the herbal formulations of vasaka. This review includes strong data about phytochemical and ethnopharmacological studies that indicate that A. vasica is a versatile native plant of the Indian subcontinent having a commercial reputation and thus can be encouraged for diversified applications like medicinal and other potential uses.
Highlights
In the manual of the World Health Organization belongs to the family Acanthaceae is commonly (WHO) for its traditional use in primary health care known as Malabar nut, adhatoda, and adulsa/adosa, [6]
Our findings suggest that A. vasica is a wonder plant, as it is utilized to heal various ailments
Another research found that Adhatoda vasica shows anti-inflammatory activity that is due to the encephalopathy from diabetic in the rat model
Summary
In the manual of the World Health Organization belongs to the family Acanthaceae is commonly (WHO) for its traditional use in primary health care known as Malabar nut, adhatoda, and adulsa/adosa,. Uterine Activity Oral administration of A. vasica leaf hydroalcoholic extract (175 mg/kg) for 10 days, causes positive abortion [10] and has significant uterine tonic and abortifacient effect due to vasicine. The aqueous extract of leaves shows significant hepatoprotective activity induced by d-galactosamine in rats at a dose less than 100 mg/kg per oral [24].
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