Abstract
Haedoxans are a series of sesquilignan natural products isolated from the traditional insecticidal plant Phryma leptostachya. Given their significant insecticidal activity, haedoxans and related analogs have been considered as potential agents for plant defense. Moreover, these compounds also exhibit promising antifungal, antibacterial, and anticancer activities. The present paper is a review of the structure, biological activity, and chemical synthesis of naturally occurring haedoxan-like molecules.
Highlights
Phryma leptostachya is a perennial herb that is widespread in nature (Lee et al, 2002; Park et al, 2005; Endo and Miyauchi, 2006; Li et al, 2019a,b; Xu et al, 2019)
Haedoxans and related neolignans are a family of natural insecticidal products with prominent potential applications
This review detailed the synthetic efforts toward haedoxans and phrymarolins in the past three decades
Summary
Reviewed by: Min Zhang, Chongqing University, China Yang Hua, Zhengzhou University, China Pei Tang, Sichuan University, China. Specialty section: This article was submitted to Organic Chemistry, a section of the journal Frontiers in Chemistry. Haedoxans are a series of sesquilignan natural products isolated from the traditional insecticidal plant Phryma leptostachya. Given their significant insecticidal activity, haedoxans and related analogs have been considered as potential agents for plant defense. These compounds exhibit promising antifungal, antibacterial, and anticancer activities. The present paper is a review of the structure, biological activity, and chemical synthesis of naturally occurring haedoxan-like molecules
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