Abstract
An asymmetric synthesis of (−)- and (+)-ketorolac was achieved with 89% ee using a novel Friedel–Crafts (FC) type C–C bond forming cyclization of an allyl alcohol containing a pyrrole ring core in the presence of a bimetallic gold(I) salt complex prepared from a 2:2:1 combination of AuCl·SMe2, AgOTf and chiral Quinaphos.
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