Abstract
A 21-residue synthetic peptide corresponding to a part of the noncatalytic domain of p60 v-src (residues 137 to 157) was found to inhibit the tyrosine kinase activity of p60 v-src. The half inhibition concentration was ca. 7.5 μM. The peptide (peptide A) did not compete with substrate proteins or ATP. Peptide A also inhibited the autophosphorylation of epidermal growth factor receptor/kinase and the tyrosine-specific protein phosphorylation in the acetylcholine receptor-rich membranes isolated from electroplax of Narke japonica. However, serine/threonine-specific protein kinases such as cAMP-dependent and cGMP-dependent protein kinases were not inhibited by peptide A.
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