Abstract
319 The main and most active component of vitamin E, α -tocopherol, is known as a potent lipophilic antioxidant and cytoprotector. It participates in intercellular signal transmission, decreases the activity of protein kinase C, inhibits the proliferation of smooth muscle cells, and controls the expression of the α -tropomyosin gene [1]. At present, hybrids of natural compounds obtained by synthetic combination of whole molecules or their fragments are used frequently as leaders in combinatorial and medicinal chemistry for designing novel pharmaceuticals [2]. Hybrids of α -tocopherol with certain natural and synthetic biologically active compounds exhibiting combined pharmacological properties and promising for the prevention and therapy of cardiovascular [3], oncological [4], inflammatory [5], and neurodegenerative diseases [6] have been obtained.
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