A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products.

Nahoko Uchiyama,Yoshihiko Shimokawa,Yosuke Demizu,Yukihiro Goda,Takashi Hakamatsuka,Ruri Kikura-Hanajiri

doi:10.1007/s11419-015-0268-7

Nahoko Uchiyama, Yoshihiko Shimokawa + Show 4 more

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https://doi.org/10.1007/s11419-015-0268-7

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Journal: Forensic toxicology	Publication Date: Feb 11, 2015
Citations: 48	License type: CC BY 4.0

Affiliation: National Institute of Health Sciences

Abstract

Six new psychoactive substances were identified together with two other substances (compounds 1–8) in illegal products by our ongoing survey in Japan between January and July 2014. A new synthetic cannabinoid, FDU-NNEI [1-(4-fluorobenzyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide, 2], was detected with the newly distributed synthetic cannabinoid FDU-PB-22 (1). Two 2H-indazole isomers of synthetic cannabinoids, AB-CHMINACA 2H-indazole analog (3) and NNEI 2H-indazole analog (4), were newly identified with 1H-indazoles [AB-CHMINACA and NNEI indazole analog (MN-18)]. In addition, 2-methylpropyl N-(naphthalen-1-yl) carbamate (5) and isobutyl 1-pentyl-1H-indazole-3-carboxylate (6) were detected in illegal products. Compound 6 is considered to be a by-product of the preparation of NNEI indazole analog from compound 5 and 1-pentyl-1H-indazole. A phenethylamine derivative, N–OH-EDMA [N-hydroxy-3,4-ethylenedioxy-N-methylamphetamine, 7], and a cathinone derivative, dimethoxy-α-PHP (dimethoxy-α-pyrrolidinohexanophenone, 8), were newly identified in illegal products. Among them, compounds 1 and 8 have been controlled as designated substances (Shitei-Yakubutsu) under the Pharmaceutical Affairs Law in Japan since August and November 2014, respectively.

Highlights

IntroductionThe consumption of new psychoactive substances (NPSs) including synthetic cannabinoids and cathinone derivatives has become widespread despite regulatory control measures [1,2,3,4,5,6,7]
Compound 6 is considered to be a by-product of the preparation of NNEI indazole analog from compound 5 and 1-pentyl-1H-indazole
The consumption of new psychoactive substances (NPSs) including synthetic cannabinoids and cathinone derivatives has become widespread despite regulatory control measures [1,2,3,4,5,6,7]

Summary

Introduction

The consumption of new psychoactive substances (NPSs) including synthetic cannabinoids and cathinone derivatives has become widespread despite regulatory control measures [1,2,3,4,5,6,7]. We previously reported the appearance of 45 newly distributed substances in Japan between January 2013 and May 2014, by our ongoing survey of NPSs in the illegal drug market in Japan [8,9,10]. The detected compounds were 18 synthetic cannabinoids, 13 cathinone derivatives, five phenethylamines, and nine other substances, including the N-methyl-D-aspartate (NMDA) channel blocker diphenidine [8,9,10]. We describe the identification of eight newly distributed compounds: four synthetic cannabinoids (1–4), two other substances (5 and 6), a phenethylamine derivative (7), and a cathinone derivative (8) in illegal products purchased from January to July 2014 (Fig. 1a)

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Conclusion