Abstract
Aim: Nicotine Substituted 1,3,4 Oxadiazole and pyrazole moieties were integrated by utilizing hydrazide as halfway .Oxadiazole were acquired by two techniques one is by utilizing PoCl3 within the sight of fragrant corrosive ,other is by utilizing carbon disulphide in the presence ofpotassium hydroxide as an impetus .Pyrazoles were likewise gotten by ehtylacetoacetate we acquired unrefined item and again it was recrystallized by utilizing alcohol.All incorporated mixtures were evaluated for Antibacterial activity and enaminones showed promising action against standard medication ciprofloxacin.
 Methods: TLC on silica gel G was used to check for homogeneity of the title compound. H NMR, Mass, and IR Spectra were used to characterise these compounds, and their antibacterial activity was tested.
 Results: All of these compounds, including nicotine substituted ester, hydrazide, 1,3,4 Oxadiazole, and pyrazole, showed antibacterial activity. The maximum activity of enaminones was comparable to that of the standard drug ciprofloxacin (5mcg). Compound1 showed potent antimicrobial activity
 Conclusion: In the zone of inhibition studies, all six samples at MIC concentrations showed reasonable antimicrobial activity Compound1 showed very good antimicrobial activity
Highlights
Among the wide range of heterocycles Oxadiazole and pyrazole have been explored to develop new therapies [1,2,3,4,5,6,7]
Oxadiazoles are five-membered heterocyclic compounds containing one oxygen and two nitrogen atoms
It is worth noting that compounds containing 1,3,4oxadiazole unit exhibit a wide range of biological activities such as anticancer, antiparasitic, antifungal, antibacterial, antidepressant, antitubercular and anti-inflammatory [9]
Summary
Among the wide range of heterocycles Oxadiazole and pyrazole have been explored to develop new therapies [1,2,3,4,5,6,7]. Oxadiazoles are five-membered heterocyclic compounds containing one oxygen and two nitrogen atoms (historically, they were known as furadiazoles). The greatest interest is involved with 1,3,4-oxadiazoles. Their high importance is highlighted by a large number of applications in various scientific areas, e.g., pharmaceutical industry, drug discovery, scintillating materials as well as dyestuff industry [8]. It is worth noting that compounds containing 1,3,4oxadiazole unit exhibit a wide range of biological activities such as anticancer, antiparasitic, antifungal, antibacterial, antidepressant, antitubercular and anti-inflammatory [9]
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