Abstract
AbstractThe racemization‐free synthesis of N‐phthaloyl amino acids (Pht‐amino acids) from amino acid esters, by using o‐methoxycarbonylbenzoyl chloride in anhydrous media, is described. The N‐phthaloyl amino acids and esters from proteins were obtained in high yields.Three N‐phthaloyl amino acids were synthesized for the first time: N‐Pht‐LTrp, N‐Pht‐S‐Bzl‐LCys and N‐Pht‐Nim‐Bzl‐LHis.In the case of some sterically hindered amino acids, LIle and α‐amino‐isobutyric acid, the intermediate N‐(o‐methoxycarbonylbenzoyl) amino acid derivative could be isolated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.