Abstract

We report a case of subacute onset of headaches and tremors with a newly discovered adrenal pheochromocytoma 23 years after an orthotopic liver transplantation and provide a review of the scarce literature regarding endocrine malignancies in liver transplant recipients. We describe the clinical presentation, diagnostic work-up, and management. This is the second case report in the literature of a de novo pheochromocytoma after solid organ transplantation. It shows that new-onset common symptoms in transplant recipients are always challenging and deserve a very thorough work-up until the cause of the symptoms is elucidated. A broad differential diagnosis should always be included in the study of any abnormalities in this patient population.

Highlights

  • Headaches are a very common symptom in adult liver transplant recipients

  • One case of de novo pheochromocytoma has been previously reported in a liver transplant recipient who presented with diabetes mellitus [3]

  • Pheochromocytomas present with episodic headache, HTN, palpitations, and sweating. In this case report we describe a patient who was diagnosed with pheochromocytoma in association with new onset of migraines 23 years after liver transplantation

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Summary

Introduction

Headaches are a very common symptom in adult liver transplant recipients. Immunosuppressant medications must always be considered a possible etiology [1] when assessing the origins of this symptom in transplant patients. Skin cancer and posttransplant lymphoproliferative disease comprise the most common malignancies after liver transplantation, followed by other solid organ cancers. One case of de novo pheochromocytoma has been previously reported in a liver transplant recipient who presented with diabetes mellitus [3]. Pheochromocytomas present with episodic headache, HTN, palpitations, and sweating. In this case report we describe a patient who was diagnosed with pheochromocytoma in association with new onset of migraines 23 years after liver transplantation

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